|
Lemon Balm (Melissa officinalis) has antiviral
properties. A cream containing an extract of Melissa officinalis has been
shown in German research to shorten the healing time of blisters and prevent
recurrence of the cold sores.
Wöhlbling RH, Leonhardt K. Local therapy of herpes simplex
with dried extract of Melissa officinalis. Phytomed 1994;1(1):25–31.
Virucidal effect was registered within 3 and 6 hours of treatment using M4
administered in MTC. The remaining extracts inactivate the virus at the 12th and
24th hour. No significant values of inhibiting activity of M1, M2, and M3 on the
same virus in vitro or in vivo were demonstrated. The presence of caffeic,
rosmarinic and ferulic acids was demonstrated by thin-layer chromatography.
Their role in the antiviral activity of M. officinalis L. is discussed.
Acta Microbiol Bulg 1993;29:65-72 Antiherpes effect of Melissa
officinalis L. extracts. Dimitrova Z, Dimov B, Manolova N, Pancheva S, Ilieva D,
Shishkov S Centre of Biogenic Stimulants, Sofia. Studies were carried out on the
virucidal and antiviral effects of Melissa officinalis L. extracts (M1, M3, M3
and M4) with respect to Herpes simplex virus type 1 (HSV-1).
Enzymatic Therapy Herpilyn contains a 70:1 concentrated melissa
(lemon balm). It guarantees to naturally soothe and soften cold sores and
fever blisters. For optimum results, apply it as soon as you feel the tingling
or itching of a cold sore coming on. 0.18 oz. tube
Melissa officinalis
Think Americans have the best
of everything? Guess again. When it comes to herbs, European commercial products
are often better than our own.
An herbal ointment for treating herpes, which is widely available in Europe,
has lemon balm as the active ingredient. The herbal content is quite
concentrated--700 milligrams of dry leaf material per gram of ointment.
In a rigorous scientific test of 116 people with herpes, the ointment
containing lemon balm was 2.5 times as effective as a similar cream without the
herb (a placebo). The herbal product was especially effective when treatment was
begun early, as the lesions were first erupting.
In another study involving 115 people using lemon balm, 96 percent had healed
completely by day 8, with no significant side effects. Normally it takes
anywhere from 10 to 14 days for herpes sores to heal. If I had herpes, and if
European lemon balm cream were available here, I'd try it. Unfortunately, it is
not, so I stick with my garden melissa.
Lemon balm
Melissa
officinalis
Source
Lemon balm is the leaf of a perennial herb in the mint family native to the
Mediterranean region, western Asia, southwestern Siberia, and northern Africa.
It is widely naturalized in North America and elsewhere.
Traditional Use
Lemon balm's history dates back at least 2,000 years. It has been used to
reduce fevers, induce sweating, calm the digestive tract, treat colds, and
relieve spasms related to cramps and headaches. In medieval Europe, the tea
was valued for disorders of the nervous system. It has long been a popular
folk remedy for insomnia. Lemon balm was official in the U. S. Pharmacopoeia
from 1840 to 1890.
Current Status
Lemon balm has been shown to be sedative, to relieve spasms, and inhibit the
growth of fungi and bacteria. The German government allows preparations of
lemon balm to be labeled for difficulty in falling asleep due to nervous
conditions and for spasms of the digestive tract.
Laboratory experiments
have shown activity against viruses including mumps and herpes simplex. A
lemon balm cream is sold in Germany for cold sores and conditions related to
herpes simplex. In a clinical study of 115 patients with herpes, a cream
containing 1 percent dried lemon balm extract was applied by the patients as
needed five times daily for up to fourteen days until healing of herpes
lesions was complete. In 96 percent of the patients, lesions were healed by
day eight of the treatment, in 87 percent by day six, and in 60 percent by day
four. Unassisted healing usually takes ten to fourteen days. A subsequent
randomized, placebo-controlled, double-blind study compared the effect of the
same cream with a placebo. Both physicians and patients judged the lemon balm
cream superior to the placebo; it was found, however, that treatment must be
started very early in the infection as accelerated healing was most pronounced
in the first two days.
Preparations
The dried leaf is available for use as tea. The fresh leaves have a much
stronger, more pleasant lemon flavor. Capsules and a cream containing a I
percent extract are sold in the American market.
Cautions
None noted.
Symptoms
Digestive gas
Herpes sores
Insomnia
Melissa (Lemon balm)
Lemon balm is indicated by the fever that accompanies infections. Lemon balm
contains polyphenols and tannins which provide antiviral effects. So far,
clinical studies have shown oral lemon balm extracts to be effective against the
viruses associated with influenza, measles, HIV and feline leukemia. Herpes
infections can be healed in less time using a topical cream containing 1% lemon
balm extract when started early and used 5 times per day.
Scientific Evidence of Melissa Officinalis
Numerous test tube studies have found that extracts of melissa possess
antiviral properties.1,2,3
Apparently, the herb blocks viruses from attaching to cells.1
Early studies of melissa ointments showed a significant reduction in the
duration and severity of herpes symptoms (both genital and oral) and, when the
cream was used regularly, a marked reduction in the frequency of recurrences. In
initial study, the melissa-treated participants recovered in 5 days, while
participants receiving nonspecific creams required 10 days.1
Researchers also described a "tremendous reduction" in the
frequency of recurrence. A subsequent double-blind study followed 116
individuals with oral or genital herpes at two dermatology centers.1
Treated subjects showed a significantly better rate of recovery than
those on placebo, according to physician and patient ratings.
A recent double-blind placebo-controlled study followed 66 individuals who
were just starting to develop a cold sore (oral herpes).4
Treatment with melissa cream produced significant benefits on day 2,
reducing the intensity of discomfort, number of blisters, and the size of the
lesion. The researchers specifically looked at day 2 because, according to them,
that is when symptoms are most pronounced. Furthermore, long-term follow-up
suggested that prophylactic use of melissa can prolong the interval before the
next herpes flare-up.
References
1. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried
extract from Melissa officinalis. Phytomedicine. 1994;1:25–31.
2. Dimitrova Z, Dimov B, Manolova N, et al. Antiherpes effect of Melissa
officinalis L. extracts. Acta Microbiol Bulg. 1993;29:65–72.
3. May G, Willuhn G. Antiviral effect of aqueous plant extracts in tissue
culture [in German; English abstract]. Arzneimittelforschung. 1978;28:1–7.
4. Koytchev R, Alken RG, Dundarov S. Balm mint extract (Lo-701) for topical
treatment of recurring Herpes labialis. Phytomedicine. 1999;6:225–230.
5. Earl Mindell, RPh.,PhD. Prescription Alternative - Chapter 20 - Drugs for
Herpes and their Natural Alternatives 1998.
|
|
|
 |
|
|
 |
Monograph : Melissa officinalis
| |

Melissa officinalis |
Common name: lemon balm
Other names: balm, common balm,
balm mint, bee balm, blue balm, cure-all, dropsy plant,
garden balm, sweet balm, folia citronellae, folia
melissae citratae, hjertensfryd, citronmelisse, melisse
Family: Lamiaceae
Parts used: above ground parts
Description
Historical Use
Cautions
Dose Dry Herb
Dose Extract
Indications
Qualities
Actions
Constituents
Toxicology
Pharmacological
Studies
Clinical Studies
Description
Originally native to the eastern Mediterranean region
and western Asia, melissa can now be found in most
temperate regions. The root is perennial, but the plant
may die back in cold climates. Its height is up to one
metre. Melissa gives off a pleasant lemon odour on
bruising the leaf. Taste is also lemony and pleasantly
spicy.
The root is short with a square and branching stem.
Leaves are opposite, stalked, about 3-4 cm long, ovate,
wrinkled, with a coarsely serrate margin and a rounded
base. Flowers are small, insignificant and whitish, in
loose small bundles in the axils of the leaves, and
bloom in summer.
Historical use
Melissa is generally considered a cure-all. Mrs Grieve
writes that it was believed to cure all complaints
associated with 'a disordered state of the nervous
system'; and mentions that Gerard, Pliny and Dioscorides
describe it as being useful 'to close up all wounds
without perill (sic) of inflammation'. Also recommended
for the treatment of all sorts of female complaints,
nervous problems, insomnia, cramps, headache, toothache,
sores, tumours, and insect bites1.
Wichtl reports the folk uses of melissa as 'functional
disturbance of the circulation' (nervous palpitations),
migraines, hysteria, and for colds as a diaphoretic,
calming and 'strengthening' remedy2.
Carmelite Balm Water, also known as Melissengeist, is a
medieval panacea made by the Carmelite monks, and is
named after lemon balm. It has sedative effects and
improves symptoms of 'vegetative dystonia' such as
restlessness, excitement, palpitations and headache3.
Carmelite Water consists mainly of distillates of
melissa (30 parts), lemon (30 parts), clove (15 parts),
cinnamon (10 parts), coriander (5 parts), marjoram (3
parts) and angelica (3 parts). Balm oil is very
expensive and is replaced by 'Indian Melissa oil', a
combination of oils from citronella and lemon grass; or
by lemon oil which has been distilled over melissa2.
_____________
1Grieve, M, 1976, A
Modern Herbal, Penguin, Middlesex, England, pp 76-7.
2Wichtl, M, 1994, Herbal
Drugs and Phytopharmaceuticals, CRC Press, Boca
Raton, Ann Arbor, pp 329-32.
3Buechner, KH,
Hellings, H, Huber, M, et al, 1974, 'Double blind study
as evidence of the therapeutic effect of Melissengeist
on psycho-vegative syndrome', Med Klin, 69(23),
pp 1032-6.
Cautions
There are no known contraindications; and no known
interactions with drugs, herbs or foods1.
A reported emmenagogic action by Leung and Foster2
is not repeated elsewhere, and the herb can be safely
used at normal infusion or extract doses during all
trimesters of pregnancy. Spiritus Melissae compositus
should be avoided because of the high alcohol content.
Infusions, extracts and tinctures can be used during
lactation.
_____________
1Wichtl M, 1994, Herbal
Drugs and Phytopharmaceuticals, CRC Press, Boca
Raton, Ann Arbor, pp 329-32.
2Leung AY, Foster S,
1996, Encyclopedia of Common Natural Ingredients Used
in Food, Drugs, and Cosmetics, John Wiley & Sons
Inc, New York, p 57.
Toxicology
There is no toxicity reported. Mutagenic potential was
screened using Aspergillus nidulans to detect
genotoxicity with aqueous or alcoholic extracts of Melissa
officinalis. No genotoxicity was observed.1
_____________
1Ramos Rui A, De la
Torre RA, Alonso N, et al, 1996, 'Screening of medicinal
plants for induction of somatic segregation activity in Aspergillus
nidulans', J Ethnopharmacol, 52(3), pp 123-7.
DoseDryHerb
6 to 12 g per day.
DoseExtract
20 to 40 mL per week (1:2).
Indications
common
cold, depression,
dyspepsia,
flatulent, dyspepsia,
nervous, fever,
flatulence,
flatulent
colic, herpes
(topically), influenza,
insomnia,
irritable
bowel syndrome, melancholia,
migraine,
neuralgia,
neurasthenia,
restlessness
Qualities
cool,
pungent
Actions
antimicrobial,
antispasmodic
(muscles), antiviral
(systemically), antiviral
(topically), carminative,
diaphoretic,
emmenagogue,
febrifuge,
sedative,
stomachic
Constituents
Constituents listed are for above ground parts, which is
the part used.1,2
Melissa contains 0.1-0.2% essential oil.
Constituents include oxygenated compounds (major
components, mainly monoterpenoid); and, citral a
(geranial) and b (neral). There are small amounts of
terpenes, mostly sesquiterpenoid. These include
beta-caryophyllene, linalool, eugenol acetate,
citronellol, geraniol, nerol, trans- and
cis-beta-ocimene, alpha-cubebene, copaene, and
beta-bourbonene.
Polyphenols include a caffeic acid, a tannin composed of
caffeic acid units, rosmarinic acid (labiate tannin),
chlorogenic acid, and protocatechuic acid. Flavonoids
(low concentrations) include luteolin-7-glucoside, and
rhamnazin. Triterpenoids include ursolic acid and
pomolic acid. Also present are glucosides of geraniol,
nerol, eugenol, neric acid and geranic acid.
The constituents from Melissa officinalis responsible
for its anti-thyrotrophic effect (see 'Pharmacological
Studies' below) are caffeic acid and its derivatives
such as rosmarinic acid and chlorogenic acid, but they
must be oxidised before they are capable of exerting an
anti-thyrotropic effect. Fluid extracts and teas do not
normally contain sufficient of these products to cause
changes in thyroid function.
The inhibition of protein buisynthesis, which has been
demonstrated in vitro (see 'Pharmacological Studies'
below), is thought to be responsible for the topical
anti-viral action of Melissa officinalis products.
_____________
1Wren, RC, 1988, Potter's
New Cyclopaedia of Botanical Drugs and Preparations,
CW Daniel Company Ltd, Essex, England, p 22-3.
2Leung, AY, Foster, S,
1996, Encyclopedia of Common Natural Ingredients Used
in Food, Drugs, and Cosmetics, John Wiley & Sons
Inc, New York, p 57.
caffeic
acid, caryophyllene
oxide, chlorogenic
acid, citral,
citronellal,
citronellol,
essential
oil, eugenol
acetate, ferulic
acid, flavonoids,
geraniol,
linalool,
polyphenolics,
rosmarinic
acid, terpenes,
triterpenoids
Pharmacological studies
Anti-inflammatory activity Rosmarinic
acid inhibits C5a generation. Rosmarinic
acid inhibits inflammatory processes
Antimicrobial activity Essential
oil of Melissa has antibacterial and fungostatic effects
Essential
oil of Melissa has anti-fungal activity Lavandula
officinalis, Melissa officinalis and Rosmarinus
officinalis show antimicrobial effects
Antimutagenic action Rosmarinus
and Melissa have antimutagenic action
Antioxidant effects Melissa
extract has antioxidant activities Melissa
has antioxidant activities Salvia
officinalis, Melissa officinalis and Lavandula
angustifolia show antioxidant effects
Anti-thyrotrophic effects Melissa
decreases TSH-binding inhibitory activity Melissa
inhibits T4 to T3 conversion Melissa
inibits binding of TSH on thyroid gland
Antiviral activity Melissa
applied topically has virostatic action Melissa
constituents have anti-viral properties Melissa
treatment for herpes simplex Melissa
used topically for herpes simplex
Central nervous system response Melissa
has sedative effect
Inhibition of protein biosynthesis Caffeic
acid inhibits protein biosynthesis Melissa
extract inibits protein biosynthesis Melissa
inibits protein biosynthesis
Clinical studies
Colitis Chronic
colitis treated with Taraxacum, Hypericum, Melissa,
Calendula and Foeniculum
Sedative effects Citronellol
from Melissa has sedative effects Improvement
of sleep quality with Valeriana and Melissa Remedy
containing oil from Melissa has sedative effect
Author: Ruth Trickey
|
 |
|
|
|
top of page
Phytotherapies.org - serving the herbal practitioner
community.
Copyright 2000 Phytotherapies.org. All rights reserved.
Contact us at info@phytotherapies.org
Another site built by RUCC
|
 |
|
|