Lemon Balm (Melissa officinalis)

Lemon Balm (Melissa officinalis) has antiviral properties. A cream containing an extract of Melissa officinalis has been shown in German research to shorten the healing time of blisters and prevent recurrence of the cold sores.
Wöhlbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract of Melissa officinalis. Phytomed 1994;1(1):25–31.

Virucidal effect was registered within 3 and 6 hours of treatment using M4 administered in MTC. The remaining extracts inactivate the virus at the 12th and 24th hour. No significant values of inhibiting activity of M1, M2, and M3 on the same virus in vitro or in vivo were demonstrated. The presence of caffeic, rosmarinic and ferulic acids was demonstrated by thin-layer chromatography. Their role in the antiviral activity of M. officinalis L. is discussed.
Acta Microbiol Bulg 1993;29:65-72 Antiherpes effect of Melissa officinalis L. extracts. Dimitrova Z, Dimov B, Manolova N, Pancheva S, Ilieva D, Shishkov S Centre of Biogenic Stimulants, Sofia. Studies were carried out on the virucidal and antiviral effects of Melissa officinalis L. extracts (M1, M3, M3 and M4) with respect to Herpes simplex virus type 1 (HSV-1). 

Enzymatic Therapy Herpilyn contains a 70:1 concentrated melissa (lemon balm). It guarantees to naturally soothe and soften cold sores and fever blisters. For optimum results, apply it as soon as you feel the tingling or itching of a cold sore coming on. 0.18 oz. tube

 

Melissa officinalis

Think Americans have the best of everything? Guess again. When it comes to herbs, European commercial products are often better than our own.

An herbal ointment for treating herpes, which is widely available in Europe, has lemon balm as the active ingredient. The herbal content is quite concentrated--700 milligrams of dry leaf material per gram of ointment.

In a rigorous scientific test of 116 people with herpes, the ointment containing lemon balm was 2.5 times as effective as a similar cream without the herb (a placebo). The herbal product was especially effective when treatment was begun early, as the lesions were first erupting.

In another study involving 115 people using lemon balm, 96 percent had healed completely by day 8, with no significant side effects. Normally it takes anywhere from 10 to 14 days for herpes sores to heal. If I had herpes, and if European lemon balm cream were available here, I'd try it. Unfortunately, it is not, so I stick with my garden melissa.

 

Lemon balm
Melissa officinalis

Source
Lemon balm is the leaf of a perennial herb in the mint family native to the Mediterranean region, western Asia, southwestern Siberia, and northern Africa. It is widely naturalized in North America and elsewhere.

Traditional Use
Lemon balm's history dates back at least 2,000 years. It has been used to reduce fevers, induce sweating, calm the digestive tract, treat colds, and relieve spasms related to cramps and headaches. In medieval Europe, the tea was valued for disorders of the nervous system. It has long been a popular folk remedy for insomnia. Lemon balm was official in the U. S. Pharmacopoeia from 1840 to 1890.

Current Status
Lemon balm has been shown to be sedative, to relieve spasms, and inhibit the growth of fungi and bacteria. The German government allows preparations of lemon balm to be labeled for difficulty in falling asleep due to nervous conditions and for spasms of the digestive tract.

Laboratory experiments have shown activity against viruses including mumps and herpes simplex. A lemon balm cream is sold in Germany for cold sores and conditions related to herpes simplex. In a clinical study of 115 patients with herpes, a cream containing 1 percent dried lemon balm extract was applied by the patients as needed five times daily for up to fourteen days until healing of herpes lesions was complete. In 96 percent of the patients, lesions were healed by day eight of the treatment, in 87 percent by day six, and in 60 percent by day four. Unassisted healing usually takes ten to fourteen days. A subsequent randomized, placebo-controlled, double-blind study compared the effect of the same cream with a placebo. Both physicians and patients judged the lemon balm cream superior to the placebo; it was found, however, that treatment must be started very early in the infection as accelerated healing was most pronounced in the first two days.

Preparations
The dried leaf is available for use as tea. The fresh leaves have a much stronger, more pleasant lemon flavor. Capsules and a cream containing a I percent extract are sold in the American market.

Cautions
None noted.

Symptoms
Digestive gas
Herpes sores
Insomnia

 

 

Melissa (Lemon balm)

Lemon balm is indicated by the fever that accompanies infections. Lemon balm contains polyphenols and tannins which provide antiviral effects. So far, clinical studies have shown oral lemon balm extracts to be effective against the viruses associated with influenza, measles, HIV and feline leukemia. Herpes infections can be healed in less time using a topical cream containing 1% lemon balm extract when started early and used 5 times per day.

Scientific Evidence of Melissa Officinalis

Numerous test tube studies have found that extracts of melissa possess antiviral properties.1,2,3 Apparently, the herb blocks viruses from attaching to cells.1

Early studies of melissa ointments showed a significant reduction in the duration and severity of herpes symptoms (both genital and oral) and, when the cream was used regularly, a marked reduction in the frequency of recurrences. In initial study, the melissa-treated participants recovered in 5 days, while participants receiving nonspecific creams required 10 days.1 Researchers also described a "tremendous reduction" in the frequency of recurrence. A subsequent double-blind study followed 116 individuals with oral or genital herpes at two dermatology centers.1 Treated subjects showed a significantly better rate of recovery than those on placebo, according to physician and patient ratings.

A recent double-blind placebo-controlled study followed 66 individuals who were just starting to develop a cold sore (oral herpes).4 Treatment with melissa cream produced significant benefits on day 2, reducing the intensity of discomfort, number of blisters, and the size of the lesion. The researchers specifically looked at day 2 because, according to them, that is when symptoms are most pronounced. Furthermore, long-term follow-up suggested that prophylactic use of melissa can prolong the interval before the next herpes flare-up.

References

1. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine. 1994;1:25–31.

2. Dimitrova Z, Dimov B, Manolova N, et al. Antiherpes effect of Melissa officinalis L. extracts. Acta Microbiol Bulg. 1993;29:65–72.

3. May G, Willuhn G. Antiviral effect of aqueous plant extracts in tissue culture [in German; English abstract]. Arzneimittelforschung. 1978;28:1–7.

4. Koytchev R, Alken RG, Dundarov S. Balm mint extract (Lo-701) for topical treatment of recurring Herpes labialis. Phytomedicine. 1999;6:225–230.

5. Earl Mindell, RPh.,PhD. Prescription Alternative - Chapter 20 - Drugs for Herpes and their Natural Alternatives 1998.

 

 

 

 

 

 
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Monograph : Melissa officinalis

  Melissa officinalis
Melissa officinalis
Common name: lemon balm

Other names: balm, common balm, balm mint, bee balm, blue balm, cure-all, dropsy plant, garden balm, sweet balm, folia citronellae, folia melissae citratae, hjertensfryd, citronmelisse, melisse

Family: Lamiaceae

Parts used: above ground parts


Description
Historical Use
Cautions
Dose Dry Herb
Dose Extract
Indications
Qualities
Actions
Constituents
Toxicology
Pharmacological Studies
Clinical Studies


Description
Originally native to the eastern Mediterranean region and western Asia, melissa can now be found in most temperate regions. The root is perennial, but the plant may die back in cold climates. Its height is up to one metre. Melissa gives off a pleasant lemon odour on bruising the leaf. Taste is also lemony and pleasantly spicy.

The root is short with a square and branching stem. Leaves are opposite, stalked, about 3-4 cm long, ovate, wrinkled, with a coarsely serrate margin and a rounded base. Flowers are small, insignificant and whitish, in loose small bundles in the axils of the leaves, and bloom in summer.

Historical use
Melissa is generally considered a cure-all. Mrs Grieve writes that it was believed to cure all complaints associated with 'a disordered state of the nervous system'; and mentions that Gerard, Pliny and Dioscorides describe it as being useful 'to close up all wounds without perill (sic) of inflammation'. Also recommended for the treatment of all sorts of female complaints, nervous problems, insomnia, cramps, headache, toothache, sores, tumours, and insect bites1.

Wichtl reports the folk uses of melissa as 'functional disturbance of the circulation' (nervous palpitations), migraines, hysteria, and for colds as a diaphoretic, calming and 'strengthening' remedy2.

Carmelite Balm Water, also known as Melissengeist, is a medieval panacea made by the Carmelite monks, and is named after lemon balm. It has sedative effects and improves symptoms of 'vegetative dystonia' such as restlessness, excitement, palpitations and headache3. Carmelite Water consists mainly of distillates of melissa (30 parts), lemon (30 parts), clove (15 parts), cinnamon (10 parts), coriander (5 parts), marjoram (3 parts) and angelica (3 parts). Balm oil is very expensive and is replaced by 'Indian Melissa oil', a combination of oils from citronella and lemon grass; or by lemon oil which has been distilled over melissa2.
_____________
1Grieve, M, 1976, A Modern Herbal, Penguin, Middlesex, England, pp 76-7.
2Wichtl, M, 1994, Herbal Drugs and Phytopharmaceuticals, CRC Press, Boca Raton, Ann Arbor, pp 329-32.
3Buechner, KH, Hellings, H, Huber, M, et al, 1974, 'Double blind study as evidence of the therapeutic effect of Melissengeist on psycho-vegative syndrome', Med Klin, 69(23), pp 1032-6.

Cautions
There are no known contraindications; and no known interactions with drugs, herbs or foods1.

A reported emmenagogic action by Leung and Foster2 is not repeated elsewhere, and the herb can be safely used at normal infusion or extract doses during all trimesters of pregnancy. Spiritus Melissae compositus should be avoided because of the high alcohol content. Infusions, extracts and tinctures can be used during lactation.
_____________
1Wichtl M, 1994, Herbal Drugs and Phytopharmaceuticals, CRC Press, Boca Raton, Ann Arbor, pp 329-32.
2Leung AY, Foster S, 1996, Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics, John Wiley & Sons Inc, New York, p 57.

Toxicology
There is no toxicity reported. Mutagenic potential was screened using Aspergillus nidulans to detect genotoxicity with aqueous or alcoholic extracts of Melissa officinalis. No genotoxicity was observed.1
_____________
1Ramos Rui A, De la Torre RA, Alonso N, et al, 1996, 'Screening of medicinal plants for induction of somatic segregation activity in Aspergillus nidulans', J Ethnopharmacol, 52(3), pp 123-7.

DoseDryHerb
6 to 12 g per day.

DoseExtract
20 to 40 mL per week (1:2).

Indications
common cold, depression, dyspepsia, flatulent, dyspepsia, nervous, fever, flatulence, flatulent colic, herpes (topically), influenza, insomnia, irritable bowel syndrome, melancholia, migraine, neuralgia, neurasthenia, restlessness

Qualities
cool, pungent

Actions
antimicrobial, antispasmodic (muscles), antiviral (systemically), antiviral (topically), carminative, diaphoretic, emmenagogue, febrifuge, sedative, stomachic

Constituents
Constituents listed are for above ground parts, which is the part used.1,2 Melissa contains 0.1-0.2% essential oil.

Constituents include oxygenated compounds (major components, mainly monoterpenoid); and, citral a (geranial) and b (neral). There are small amounts of terpenes, mostly sesquiterpenoid. These include beta-caryophyllene, linalool, eugenol acetate, citronellol, geraniol, nerol, trans- and cis-beta-ocimene, alpha-cubebene, copaene, and beta-bourbonene.

Polyphenols include a caffeic acid, a tannin composed of caffeic acid units, rosmarinic acid (labiate tannin), chlorogenic acid, and protocatechuic acid. Flavonoids (low concentrations) include luteolin-7-glucoside, and rhamnazin. Triterpenoids include ursolic acid and pomolic acid. Also present are glucosides of geraniol, nerol, eugenol, neric acid and geranic acid.

The constituents from Melissa officinalis responsible for its anti-thyrotrophic effect (see 'Pharmacological Studies' below) are caffeic acid and its derivatives such as rosmarinic acid and chlorogenic acid, but they must be oxidised before they are capable of exerting an anti-thyrotropic effect. Fluid extracts and teas do not normally contain sufficient of these products to cause changes in thyroid function.

The inhibition of protein buisynthesis, which has been demonstrated in vitro (see 'Pharmacological Studies' below), is thought to be responsible for the topical anti-viral action of Melissa officinalis products.
_____________
1Wren, RC, 1988, Potter's New Cyclopaedia of Botanical Drugs and Preparations, CW Daniel Company Ltd, Essex, England, p 22-3.
2Leung, AY, Foster, S, 1996, Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics, John Wiley & Sons Inc, New York, p 57.

caffeic acid, caryophyllene oxide, chlorogenic acid, citral, citronellal, citronellol, essential oil, eugenol acetate, ferulic acid, flavonoids, geraniol, linalool, polyphenolics, rosmarinic acid, terpenes, triterpenoids

Pharmacological studies
Anti-inflammatory activity Rosmarinic acid inhibits C5a generation. Rosmarinic acid inhibits inflammatory processes

Antimicrobial activity Essential oil of Melissa has antibacterial and fungostatic effects Essential oil of Melissa has anti-fungal activity Lavandula officinalis, Melissa officinalis and Rosmarinus officinalis show antimicrobial effects

Antimutagenic action Rosmarinus and Melissa have antimutagenic action

Antioxidant effects Melissa extract has antioxidant activities Melissa has antioxidant activities Salvia officinalis, Melissa officinalis and Lavandula angustifolia show antioxidant effects

Anti-thyrotrophic effects Melissa decreases TSH-binding inhibitory activity Melissa inhibits T4 to T3 conversion Melissa inibits binding of TSH on thyroid gland

Antiviral activity Melissa applied topically has virostatic action Melissa constituents have anti-viral properties Melissa treatment for herpes simplex Melissa used topically for herpes simplex

Central nervous system response Melissa has sedative effect

Inhibition of protein biosynthesis Caffeic acid inhibits protein biosynthesis Melissa extract inibits protein biosynthesis Melissa inibits protein biosynthesis

Clinical studies
Colitis Chronic colitis treated with Taraxacum, Hypericum, Melissa, Calendula and Foeniculum

Sedative effects Citronellol from Melissa has sedative effects Improvement of sleep quality with Valeriana and Melissa Remedy containing oil from Melissa has sedative effect

Author: Ruth Trickey





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